Home Research Area Brain Cancer

Brain Cancers

In 2022, the global incidence of brain and central nervous system (CNS) cancers was estimated to be over 320,000.1 GBM is the most common malignant primary brain tumor, accounting for roughly 15% of all primary brain tumors and about 50% of all malignant gliomas.2

Our brain cancer program targets two proteins known as large amino acid transporters 1 and 2 (LAT1 and LAT2). These proteins, are found in several solid tumors, including tumors of the CNS. Telix believes that the LAT1 and LAT2 receptors, which are found on both sides of the blood-brain barrier (BBB), are suitable targets for the delivery of radiation to both primary CNS tumors and tumors that have spread from non-CNS cancers such as lung and breast cancer.

GBM often has poor outcomes, primarily due to there being few effective treatment options. The main treatment is surgery, followed by combined radiotherapy and chemotherapy. Despite such treatment, recurrence occurs in almost all patients.

.

Our brain cancer portfolio
Our brain cancer trials

Our brain cancer portfolio

  • Therapeutics

    • TLX101 (131I-IPA)

      Telix’s investigational therapy for GBM, is currently being evaluated in newly diagnosed and recurrent GBM in the IPAX series of studies.

  • Diagnostics

    • TLX101-CDx (18F-floretyrosine or 18F-FET)

      Telix’s investigational PET agent for imaging gliomas, widely used in clinical research settings including in Telix’s IPAX studies as a complementary diagnostic agent to the company’s TLX101 GBM investigational therapy.

Active Trials

Active trials for Brain Cancer / Glioblastoma

View all trials

IPAX-2
Recruiting
Australia ,  Europe ,  New Zealand , 
TLX101 for Treatment of Newly Diagnosed Glioblastoma
Find out more
  1. Filho, A. M., Znaor, A., Sunguc, C., Zahwe, M., Marcos-Gragera, R., Figueroa, J. D., & Bray, F. (2025). Cancers of the brain and central nervous system: Global patterns and trends in incidence. Journal of Neuro-Oncology, 172(3), 567–578. https://doi.org/10.1007/s11060-025-04944-y
  2. Kanderi, T., Munakomi, S., & Gupta, V. (2024, May 6). Glioblastoma multiforme. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK558954/